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R Rajagopalan, Ph.D  

Born:  May 20, 1950                                                      
Nationality:  Indian
 

Contact

  
 

Chief Scientific Officer, Dr Kallam Anji Reddy Distinguished Chair of Diabetes Research, Madras Diabetes Research Foundation,  Kallam Anji Reddy Centre, Women’s Biotech Park, Siruseri, Chennai 603 103, Tamil Nadu, India. phone: 97910 17172,  91 44 4740 5902, drrajagopalan@hotmail.com, drrajagopalan@mdrf.com
 

PROFILE
 

A discovery research-scientist and a thought leader in the area of cardiovascular, metabolic, inflammation oncology and toxicology research and has work experience in  India and Germany since 1973.  Starting his career in discovery research, he has moved through a number of drug discovery research related roles of increasing responsibility, including Clinical development of NCEs, business development and licensing of NCEs  preclinical or clinical stage development  to various multinational companies.  In the current position as Chief Scientific Officer, Madras Diabetes Research Foundation, he has overall responsibility of both basic and clinical research related to diabetes and its complications. The most recent position held was with Dr Reddy’s Laboratories Ltd., India, where he was President Drug Discovery Research and a member of the Corporate Management Council. 

During this tenure, his team has  successfully established an operationalized  the state-of-the-art research  and Clinical Development facilities at Dr Reddys by employing careful planning and precise control with emphasis on quality, timelines and development partner satisfaction. Most important aspect of establishing full fledged animal pharmacology, GLP approved toxicology centre of excellence and other facilities in Dr Reddys.   While serving in Dr Reddys and Hoechst India Ltd., he successfully executed this with many collaborators like Novartis, Novo Nordisk, Merck, GSK, Rheoscience, ClinTec etc., and other government/academic institutes like: NIH, St Jude’s Hospital, Northwestern University, US and European Regulatory Authorities, Drug Controller General Office of India, in both Dr Reddys and Hoechst India Ltd. 

  • As a leader – through personal example, empowerment, support, and good line of communication he successfully managed the Indian and US operations.  
As a Management Council Member, he was closely associating with the Chairman, CEO and other management council members in strategizing the R & D and other business plans of Dr Reddys.  He has  good ability to articulate and implement business strategy and to communicate this to senior management and down the line to obtain support and commitment.   Dr R Rajagopalan has been acknowledged as one of the architect of Dr Reddy’s successful drug discovery team.
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  Career Advancement
 

2008- May

Chief Scientific Officer,  Madras Diabetes Research Foundation, Siruseri,  Chennai

2008  - 2007

Principal Consultant, Envivo Lifescience, Bangalore

2007 - 1994

Dr. Reddy’s Laboratories Ltd.,
President Discovery Research April 2001 to June 2007
Management Council Member
Senior Vice President     April 1999 to March 2001
Vice President                April 1996 to March 1999
General Manager            April 1994 to April 1996

 

Accomplishments

  • 2005 India’s first integrated drug development company –“Perlecan Pharma Private Limited”
  • 2005 Co-development and commercialization agreement with Rheoscience for Balaglitazone for the treatment of type 2 diabetes
  • A similar agreement with ClinTec for development of anticancer molecules DRF 1042
  • 2003 coordinated the activity in creating structure based drug design organization Aurigene
  • Obtained GLP certification from Indian and Netherlands authorities for our toxicology facility
  • 2001 Successfully negotiated the out-license of DRF 4158 insulin sensitizer molecule to Novartis
  • 2000 Reddy US Therapeutics, a wholly owned subsidiary is launched in US
  • 1998 Successfully licensed antidiabetic molecule Ragaglitazar to Novo Nordisk
  • 1997 Licensed Balaglitazone molecule to Novo Nordisk
  • 1994 Established the state-of-the-art research facility in Miyapur, Hyderabad.

1994-1973

Hoechst India Ltd.,
Principal Research Scientist- Research Officer                                  

 

Milestones

  • Discovery of  Forskolin a unique adenylate cyclase activator (currently used as biochemical tool)
  • Ramipril – ACE inhibitor discovery team member
  • Baralgan analogue research
  #
 

EDUCATIONAL QUALIFICATIONS

B. Sc 1970

University of Madras

M.Sc Pharmacology 1973

Faculty of Medicine, University of Madras, Rank holder

Ph D Pharmacology 1983

Faculty of Medicine, University of Bombay

PDF 1986

Heidelberg University, Germany

Visiting Faculty1989-93

University of Department of Chemical Technology, Bombay University, India.

Advisory Role

  • Examiner for M. Pharm course and Ph.D. in Bombay University, India
  • Bombay University Selection Committee member.
  • Member of Adhoc Board of studies in Pharmacy, Jawaharlal Nehru Tech.University, Hyderabad, India

Professional Affiliations

  • The International Pharmacological Association
  • The American Diabetes Association
  • The American Heart Association
  • The Indian Pharmacological Association
  • The Indian Cancer Association
  • The Japanese Natural Product Society

(Wakan Yaku)

Awards
  • Prof. R.N. Chopra Oration Award from Indian Pharmacological Society
 

Number of Papers Presented in various National and International Meetings: 30
Named as inventor and co inventor in more than 50 Patents

 

Publications:
 
  1. Bibliographic Information
    In vitro and in vivo antibacterial evaluation of DRF 8417, a new oxazolidinone. Sreenivas, K.; Amarnath, P. V. S.; Mallik, A.; Sarnaik, H.; Kumar, N. Selva; Takhi, M.; Trehan, S.; Kumar, M. Sitaram; Iqbal, J.; Rajagopalan, R.; Chakrabarti, R. Anti-infective Group, Discovery Research, Dr Reddy's Laboratories Ltd, Hyderabad, India. Journal of Antimicrobial Chemotherapy (2007), 60(1), 159-161.
  2. Bibliographic Information
    Antihypertensive effect of ragaglitazar: A novel PPARα and γ dual activator. Mamnoor, Prem K.; Hegde, Pragathi; Datla, Srinivas R.; Damarla, Ravi K. B.; Rajagopalan, Ramanujam; Chakrabarti, Ranjan. Discovery Biology, Dr. Reddy's Laboratories Ltd.-Discovery Research, Hyderabad, India. Pharmacological Research (2006), 54(2), 129-135.
  3. Bibliographic Information
    Synthesis of potent water soluble forskolin analogs. Lal, Bansi; Gangopadhyay, Ashok Kumar; Gidwani, Ramesh M.; Rajagopalan, Ramanujam; Ghate, Anil V. Department of Chemistry, Quest Institute of Life Sciences, Mumbai, India. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2006), 45B(1), 232-246.
  4. Bibliographic Information
    Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential. Madhavan, Gurram R.; Chakrabarti, Ranjan; Reddy, K. Anantha; Rajesh, B. M.; Balraju, V.; Rao, P. Bheema; Rajagopalan, R.; Iqbal, Javed. Discovery Chemistry, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Bioorganic & Medicinal Chemistry (2006), 14(2), 584-591.  
  5. Bibliographic Information
    Pro-drug of forskolin and its 2-hydroxyacyl analogs. Lal, Bansi; Gangopadhyay, Ashok Kumar; Rajagopalan, Ramanujam; Ghate, Anil V. Department of Chemistry, Quest Institute of Life Sciences, Mumbai, India. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2005), 44B(11), 2308-2313.
  6. Bibliographic Information
    DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF7 breast cancer cells. Satyanarayana, Chitkala; Deevi, Dhanvanthri S.; Rajagopalan R; Srinivas, Nanduri; Rajagopal, Sriram. Discovery Research, Dr Reddy's Laboratories, Hyderabad, India. BMC Cancer (2004), 4 No pp. given. Publisher: BioMed Central Ltd.,
  7. Bibliographic Information
    The role of PPARs in obesity and other insulin resistance associated disorders. Chakrabarti, R.; Rajagopalan, R.. Discovery Biology, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Current Medicinal Chemistry: Immunology, Endocrine & Metabolic Agents (2004), 4(2), 67-73. Publisher: Bentham Science Publishers Ltd.
  8. Bibliographic Information
    Novel routes for the generation of structurally diverse labdane diterpenes from andrographolide. Nanduri, Srinivas; Nyavanandi, Vijay Kumar; Thunuguntla, Siva Sanjeeva Rao; Velisoju, Mahendar; Kasu, Sridevi; Rajagopal, Sriram; Kumar, R. Ajaya; Rajagopalan, R.; Iqbal, Javed. Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, India. Tetrahedron Letters (2004), 45(25), 4883-4886.
  9. Bibliographic Information
    Antidiabetic and hypolipidemic potential of DRF 2519-a dual activator of PPAR-α and PPAR-γ Chakrabarti, Ranjan; Misra, Parimal; Vikramadithyan, Reeba K.; Premkumar, Mamnoor; Hiriyan, Jagadheshan; Datla, Srinivas R.; Damarla, Ravi K. B.; Suresh, Juluri; Rajagopalan, Ramanujam. Discovery Biology, Dr. Reddy's Laboratory-Discovery Research, Hyderabad, India. European Journal of Pharmacology (2004), 491(2-3), 195-206.
  10. Bibliographic Information
    Influence of ethylene-oxy spacer group on the activity of linezolid: Synthesis of potent antibacterials possessing a thiocarbonyl group. Selvakumar, N.; Raheem, Mohammed A.; Khera, Manoj Kumar; Rajale, Trideep V.; Kumar, Magadi Sitaram; Kandepu, Sreenivas; Das, Jagattaran; Rajagopalan, R.; Iqbal, Javed; Trehan, Sanjay. Anti-infectives Discovery Group, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (2003), 13(23), 4169-4172.
  11. Bibliographic Information
    Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. Rajagopal, Sriram; Kumar, R. Ajaya; Deevi, Dhanvanthri S.; Satyanarayana, Chitkala; Rajagopalan, R.. Discovery Research, Dr. Reddy's Laboratories, Hyderabad, India. Journal of Experimental Therapeutics and Oncology (2003), 3(3), 147-158.
  12. Bibliographic Information
    Ragaglitazar: A novel PPARα & PPARγ agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models. Chakrabarti, Ranjan; Vikramadithyan, Reeba K.; Misra, Parimal; Hiriyan, Jagadheshan; Raichur, Suryaprakash; Damarla, Ravi K.; Gershome, Cynthia; Suresh, Juluri; Rajagopalan, Ramanujam. Discovery Biology, Dr Reddy's Laboratories-Discovery Research, Hyderabad, India. British Journal of Pharmacology (2003), 140(3), 527-537.
  13. Bibliographic Information
     Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss. Nanduri, Srinivas; Thunuguntla, Siva Sanjeeva Rao; Nyavanandi, Vijay Kumar; Kasu, Sridevi; Kumar, P. Mahesh; Ram, P. Sai; Rajagopal, Sriram; Kumar, R. Ajaya; Deevi, Dhanvanthri S.; Rajagopalan, R.; Venkateswarlu, A. Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (2003), 13(22), 4111-4115.
  14. Bibliographic Information
    New styryl sulfones as anticancer agents. Vedula, Manohar Sharma; Pulipaka, Aravind Babu; Venna, Chandrasekhar; Chintakunta, Vamsee Krishna; Jinnapally, Sreenu; Kattuboina, Venkata Adiseshu; Vallakati, Ravi Krishna; Basetti, Vishnu; Akella, Venkateswarlu; Rajgopal, Sriram; Reka, Ajaya Kumar; Teepireddy, Sravan Kumar; Mamnoor, Prem Kumar; Rajagopalan, Ramanujam; Bulusu, Gopalakrishnan; Khandelwal, Akash; Upreti, Vijay V.; Mamidi, Srinivas Rao. Discovery Research, Discovery Chemistry, Dr. Reddy's Laboratories, Hyderabad, India. European Journal of Medicinal Chemistry (2003), 38(9), 811-824.
  15. Bibliographic Information
    PAT5A: A partial agonist of peroxisome proliferator-activated receptor γ is a potent antidiabetic thiazolidinedione yet weakly adipogenic. Misra, Parimal; Chakrabarti, Ranjan; Vikramadithyan, Reeba K.; Gopalakrishnan, B.; Suresh, J.; Jagadheshan, H.; Cynthia, G.; Rajjak, Abdul; Kashireddy, Papreddy; Songtaoyu; Surapureddi, Sailesh; Qi, Chao; Zhu, Yi-Jun; Rao, Sambasiva; Reddy, Janardan K.; Rajagopalan, R.. Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Journal of Pharmacology and Experimental Therapeutics (2003), 306(2), 763-771.
  16. Bibliographic Information
    Oral bioavailability and pharmacokinetics of DRF-4367, a new cox-2 inhibitor in rats. Ramesh, Mullangi; Mamidi, Rao N. V. S.; Jagannath, Kota; Singh, Sunil Kumar; Rao, Kalleda Srinivasa; Rao, Yeleswarapu Koteswar; Seshagirirao, Casturi; Rajagopalan, Ramanujam; Srinivas, Nuggehally R. Research Bioanalysis, Metabolism and Pharmacokinetic Laboratories, Dr. Reddy's Laboratories Ltd., Hyderabad, India. European Journal of Drug Metabolism and Pharmacokinetics (2003), 28(2), 137-141.
  17. Bibliographic Information
    Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents. Sharma, Vedula M.; Adi Seshu, K. V.; Vamsee Krishna, C.; Prasanna, P.; Chandra Sekhar, V.; Venkateswarlu, A.; Rajagopal, Sriram; Ajaykumar, R.; Deevi, Dhanvanthri S.; Rao Mamidi, N. V. S.; Rajagopalan, R.. Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories, Miyapur, Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (2003), 13(10), 1679-1682.
  18. Bibliographic Information
    DRF 2655: a unique molecule that reduces body weight and ameliorates metabolic abnormalities. Vikramadithyan, Reeba K.; Hiriyan, Jagadheshan; Suresh, Juluri; Gershome, Cynthia; Babu, Ravi K.; Misra, Parimal; Rajagopalan, Ramanujam; Chakrabarti, Ranjan. Discovery Biology, Discovery Research, Dr. Reddy's Laboratories, Hyderabad, India. Obesity Research (2003), 11(2), 292-303.
  19. Bibliographic Information
    Diabetes and insulin resistance associated disorders: disease and the therapy. Chakrabarti, Ranjan; Rajagopalan, Ramanujam. Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad, India. Current Science (2002), 83(12), 1533-1538.
  20. Bibliographic Information
    Quantitative determination of Ragaglitazar in rat plasma by HPLC: validation and application in pharmacokinetic study. Kota, Jagannath; Mullangi, Ramesh; Mamidi, Rao N. V. S.; Rajagopalan, Ramanujam. Bioanalysis, Metabolism and Pharmacokinetics Laboratories, Discovery Research, Dr. Reddy's Laboratories Ltd, Hyderabad, India. Biomedical Chromatography (2002), 16(8), 495-499.
  21. Bibliographic Information
    Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats. Mamidi, Rao N. V. S.; Mullangi, Ramesh; Kota, Jagannath; Bhamidipati, Ravikanth; Khan, Ansar A.; Katneni, Kasiram; Datla, Srinivasaraju; Singh, Sunil K.; Rao, Koteswar Y.; Rao, C. Seshagiri; Srinivas, Nuggehally R.; Rajagopalan, Ramanujam. Laboratories of Bioanalysis, Drug Metabolism and Pharmacokinetics, Dr Reddy's Research Foundation, Hyderabad, India. Biopharmaceutics & Drug Disposition (2002), 23(7), 273-282.
  22. Bibliographic Information
    PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes. Chakrabarti, R.; Vikramadithyan, R. K.; Kumar, M. Prem; Kumar, S. K. B.; Mamidi, N. V. S.; Misra, P.; Suresh, J.; Hiriyan, J.; Rao, C. S.; Rajagopalan, R.. Discovery Biology, Dr Reddy's Research Foundation, Hyderabad, India. Diabetes, Obesity and Metabolism (2002), 4(5), 319-328.
  23. Bibliographic Information
    HPLC method for the determination of rosiglitazone in human plasma and its application in a clinical pharmacokinetic study. Mamidi, Rao N. V. S.; Chaluvadi, Madhusudana R.; Benjamin, Biju; Ramesh, Mullangi; Katneni, Kasiram; Babu, Aravinda P.; Bhanduri, Jaydip; Rao, Naidu M. U.; Rajagopalan, Ramanujam. Drug Metabolism and Pharmacokinetics Laboratory, Department of Preclinical Biology, Dr. Reddy's Research Foundation, Hyderabad, India. Arzneimittel-Forschung (2002), 52(7), 560-564.
  24. Bibliographic Information
    Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship. Sharma, Vedula M.; Prasanna, P.; Adi Seshu, K. V.; Renuka, B.; Laxman Rao, C. V.; Sunil Kumar, G.; Narasimhulu, C. Prasad; Aravind Babu, P.; Puranik, R. C.; Subramanyam, D.; Venkateswarlu, A.; Rajagopal, Sriram; Kumar, K. B. Sunil; Rao, C. Seshagiri; Mamidi, N. V. S. Rao; Deevi, Dhanvanthri S.; Ajaykumar, R.; Rajagopalan, R.. Discovery Chemistry (Natural Products), Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (2002), 12(17), 2303-2307.
  25. Bibliographic Information
    Synthesis of Conformationally Constrained Analogs of Linezolid: Structure-Activity Relationship (SAR) Studies on Selected Novel Tricyclic Oxazolidinones. Selvakumar, Natesan; Srinivas, Deekonda; Khera, Manoj Kumar; Kumar, Magadi Sitaram; Mamidi, Rao N. V. S.; Sarnaik, Hemanth; Charavaryamath, Chandrashekar; Rao, Bonthu Srinivasa; Raheem, Mohammed A.; Das, Jagattaran; Iqbal, Javed; Rajagopalan, Ramanujam. Anti-Infectives Discovery Group, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Medicinal Chemistry (2002), 45(18), 3953-3962.
  26. Bibliographic Information
    Lack of effect of sucralfate on the absorption and pharmacokinetics of rosiglitazone. Rao, Mamidi N. V. S.; Mullangi, Ramesh; Katneni, Kasiram; Ravikanth, Bhamidipati; Babu, Aravind P.; Rani, Usha P.; Naidu, M. U. R.; Srinivas, Nuggehally R.; Rajagopalan, Ramanujam. Bioanalysis, Drug Metabolism, and Pharmacokinetics Laboratory, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Clinical Pharmacology (2002), 42(6), 670-675.
  27. Bibliographic Information
    Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives. Madhavan, Gurram R.; Chakrabarti, Ranjan; Vikramadithyan, Reeba K.; Mamidi, Rao N. V. S.; Balraju, V.; Rajesh, B. M.; Misra, Parimal; Kumar, Sunil K. B.; Lohray, Braj B.; Lohray, Vidya B.; Rajagopalan, Ramanujam. Dr. Reddy's Research Foundation, Hyderabad, India. Bioorganic & Medicinal Chemistry (2002), 10(8), 2671-2680.
  28. Bibliographic Information
    3-O-Substituted benzyl pyridazinone derivatives as COX inhibitors. Chintakunta, Vamsee Krishna; Akella, Venkateswarlu; Vedula, Manohar Sharma; Mamnoor, Prem Kumar; Mishra, Parimal; Casturi, Seshagiri Rao; Vangoori, Akhila; Rajagopalan, Ramanujam. Discovery Chemistry, Dr. Reddy's Research Foundation, Hyderabad, India. European Journal of Medicinal Chemistry (2002), 37(4), 339-347.
  29. Bibliographic Information
    Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents. Madhavan, G. R.; Chakrabarti, R.; Kumar, S. K. B.; Misra, P.; Mamidi, R. N. V. S.; Balraju, V.; Kasiram, K.; Babu, R. K.; Suresh, J.; Lohray, B. B.; Lohrayb, V. B.; Iqbal, J.; Rajagopalan, R.. Discovery Chemistry, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India. European Journal of Medicinal Chemistry (2001), 36(7-8), 627-637.
  30. Bibliographic Information
    (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(-)DRF 2725]: A Dual PPAR Agonist with Potent Antihyperglycemic and Lipid Modulating Activity. Lohray, Braj B.; Lohray, Vidya B.; Bajji, Ashok C.; Kalchar, Shivaramayya; Poondra, Rajamohan R.; Padakanti, Srinivas; Chakrabarti, Ranjan; Vikramadithyan, Reeba K.; Misra, Parimal; Juluri, Suresh; Mamidi, N. V. S. Rao; Rajagopalan, Ramanujam. Discovery Synthesis and Discovery Biology, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Medicinal Chemistry (2001), 44(16), 2675-2678.
  31. Bibliographic Information
    Euglycemic and hypolipidemic activity of PAT5A: a unique thiazolidinedione with weak peroxisome proliferator activated receptor gamma activity. Vikramadithyan, Reeba K.; Chakrabarti, Ranjan; Misra, Parimal; Premkumar, Mamnoor; Kumar, Sunil K. B.; Rao, Casturi S.; Ghosh, Alpana; Reddy, Kommireddi N.; Uma, Chintakunta; Rajagopalan, Ramanujam. Preclinical Biology, Dr. Reddy's Research Foundation, Hyderabad, India. Metabolism, Clinical and Experimental (2000), 49(11), 1417-1424.
  32. Bibliographic Information
    Studies on the euglycemic and hypolipidemic potentials of the novel indole analogue of thiazolidinedione, DRF 2189. Chakrabarti, Ranjan; Vikramadithyan, Reeba Kannimel; Dileepkumar, Tripuraneni; Kumar, Kochunarayanapillai Bhadramma Sunil; Kumar, Mamnoor Prem; Misra, Parimal; Rao, Paraselli Bheema; Lohray, Vidya Bhusan; Lohray, Braj Bhusan; Rajagopalan, Ramanujam. Department of Pharmacology, Dr. Reddy's Research Foundation, Hyderabad, India. Arzneimittel-Forschung (1999), 49(11), 905-911.
  33. Bibliographic Information
    Novel Antidiabetic and Hypolipidemic Agents. 5. Hydroxyl versus Benzyloxy Containing Chroman Derivatives. Reddy, K. Anji; Lohray, B. B.; Bhushan, V.; Reddy, A. Sekar; Rao Mamidi, N. V. S.; Reddy, P. Papi; Saibaba, V.; Reddy, N. Jaipal; Suryaprakash, A.; Misra, Parimal; Vikramadithyan, Reeba K.; Rajagopalan, R.. Medicinal and Organic Chemistry Clinical Research Pharmacology, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Medicinal Chemistry (1999), 42(17), 3265-3278.
  34. Bibliographic Information
    Novel euglycemic and hypolipidemic agents: pyridine containing unsaturated thiazolidinediones. Lohray, B. B.; Bhushan, Vidya; Reddy, A. Sekar; Rao, P. Bheema; Reddy, N. Jaipal; Reddy, K. Anantha; Vikramadithyan, Reeba K.; Rajagopalan, R.. Department of Medicinal Chemistry and Drug Discovery, Dr. Reddy's Research Foundation, Hyderabad, India. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1999), 38B(4), 403-406.
  35. Bibliographic Information
    Anti-ulcer potential of Haldinia cordifolia. Kasinadhuni, V. R. R.; Rajashekhar, G.; Rajagopalan, R.; Sharma, V. M.; Krishna, C. Vamsi; Sairam, P.; Prasad, G. Sai; Sadhukhan, S.; Rao, G. Gangadhar. Pharmacology R and D, Dr Reddy's Research Foundation, Hyderabad, India. Fitoterapia (1999), 70(1), 93-95.
  36. Bibliographic Information
    Novel euglycemic and hypolipidemic agents. 4. Pyridyl- and quinolinyl-containing thiazolidinediones. Lohray, B. B.; Bhushan, Vidya; Reddy, A. Sekar; Rao, P. Bheema; Reddy, N. Jaipal; Harikishore, P.; Haritha, N.; Vikramadityan, Reeba K.; Chakrabarti, Ranjan; Rajagopalan, R.; Katneni, K. Departments of Medicinal Chemistry and Drug Discovery Pharmacology and Pharmacokinetics, Dr. Reddy's Research Foundation, Miyapur Hyderabad, India. Journal of Medicinal Chemistry (1999), 42(14), 2569-2581.
  37. Bibliographic Information
    Novel antidiabetic and hypolipidemic agents. 3. Benzofuran-containing thiazolidinediones. Reddy, K. Anji; Lohray, B. B.; Bhushan, V.; Bajji, A. C.; Reddy, K. Vivekananda; Reddy, P. Rajamohan; Krishna, T. Hari; Rao, I. Nageswara; Jajoo, H. Kumar; Rao, N. V. S. Mamidi; Chakrabarti, Ranjan; Dileepkumar, T.; Rajagopalan, R.. Medicinal and Organic Chemistry Drug Metabolism and Pharmacokinetics and Pharmacology, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Medicinal Chemistry (1999), 42(11), 1927-1940.
  38. Bibliographic Information
    Design and synthesis of new water soluble forskolin derivatives for positive inotropic activity. Lal, Bansi; Gangopadhyay, Ashok Kumar; Rajagopalan, Ramanujam; Ghate, Anil Vasantrao. Department of Chemistry, Research Centre, Hoechst Marrion Roussel Limitted, Mumbai, India. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1998), 37B(10), 979-987.
  39. Bibliographic Information
    In search of novel water soluble forskolin analogs for positive inotropic activity. Lal, Bansi; Gangopadhyay, Ashok Kumar; Gidwani, Ramesh M.; Fernandes, Magno; Rajagopalan, Ramanujam; Ghate, Anil Vasantrao. Department of Chemistry, Research Centre, Hoechst Marion Roussel Limited, Mumbai, India. Bioorganic & Medicinal Chemistry (1998), 6(11), 2075-2083.
  40. Bibliographic Information
    Hydroxyacyl derivatives of forskolin-their positive inotropic activity. Lal, Bansi; Gangopadhyay, Ashok Kumar; Rajagopalan, Ramanujam; Ghate, Anil Vasantrao. Department of Chemistry, Research Centre, Hoechst Marion Roussel Limited, Mumbai, India. Bioorganic & Medicinal Chemistry (1998), 6(11), 2061-2073.
  41. Bibliographic Information
    Synthesis and biological activity of novel thiazolidinediones. Prabhakar, C.; Madhusudhan, G.; Sahadev, K.; Reddy, Ch. Maheedhara; Sarma, M. R.; Reddy, G. Om; Chakrabarti, R.; Rao, C. Seshagiri; Kumar, T. Dileep; Rajagopalan, R.. Department of Process Research and Development, Department of Pharmacology, Dr. Reddy's Research Foundation, Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (1998), 8(19), 2725-2730.
  42. Bibliographic Information
    Novel euglycemic and hypolipidemic agents. part 2: antioxidant moiety as structural motif. Reddy, K. Anji; Lohray, B. B.; Bhushan, Vidya; Reddy, A. Sekar; Kishore, P. Hari; Rao, V. Venugopal; Saibaba, V.; Bajji, A. C.; Rajesh, B. M.; Reddy, K. Vivekananda; Chakrabarti, Ranjan; Rajagopalan, R.. Dr. Reddy's Research Foundation, Hyderabad, India. Bioorganic & Medicinal Chemistry Letters (1998), 8(15), 2059.
  43. Bibliographic Information
    Novel Euglycemic and Hypolipidemic Agents. 1. Lohray, Braj B.; Bhushan, Vidya; Bheema Rao, P.; Madhavan, Gurram R.; Murali, Nagabelli; Rao, Krovvidi N.; Reddy, Ananth K.; Rajesh, Bagepalli M.; Reddy, Pamulapati G.; Chakrabarti, Ranjan; Vikramadithyan, Reeba K.; Rajagopalan, Ramanujam; Mamidi, Rao N. V. S.; Jajoo, Hemant K.; Subramaniam, Swaminathan. Medicinal and Organic Chemistry Pharmacology and Clinical Research, Dr. Reddy's Research Foundation, Hyderabad, India. Journal of Medicinal Chemistry (1998), 41(10), 1619-1630.
  44. Bibliographic Information
    HL 752: a potent and long-acting antispasmodic agent. Bal-Tembe, Swati; Bhedi, Dilip N.; Mishra, Anil K.; Rajagopalan, Ramanujam; Ghate, Anil V.; Subbarayan, Palakodety; Punekar, Narayan S.; Kulkarni, Anjali V. Res. Cent., Hoechst Marion Roussel Ltd., Bombay, India. Bioorganic & Medicinal Chemistry (1997), 5(7), 1381-1387.
  45. Bibliographic Information
    Cardiotonic activity of the water soluble forskolin derivative 8,13-epoxy-6β -(piperidinoacetoxy)-1α ,7β ,9α -trihydroxy-labd-14-en-11-one. Rajagopalan, R.; Ghate, A. V.; Subbarayan, P.; Linz, W.; Schoelkens, B. A. Hoechst India Ltd., Bombay, India. Arzneimittel-Forschung (1993), 43(3), 313-19.
  46. Bibliographic Information
    HL 752, a new enteral active muscarinic receptor antagonist. Bickel, M.; Bal-Tembe, S.; Blumbach, J.; Dohadwalla, A. N.; Lal, B.; Palm, D.; Rajagopalan, R.; Rupp, R. H.; Schmidt, D.; Volz-Zang, C. Hoechst A.-G., Frankfrut, Germany. Medical Science Research (1990), 18(22), 877-9.
  47. Bibliographic Information
    Cardiovascular effects of new water-soluble derivatives of forskolin. Khandelwal, Y.; Rajeshwari, K.; Rajagopalan, R.; Swamy, Lakshmi; Dohadwalla, A. N.; De Souza, N. J.; Rupp, R. H. Cent. Basic Res., Hoechst India Ltd., Bombay, India. Journal of Medicinal Chemistry (1988), 31(10), 1872-9.
  48. Bibliographic Information
    Occurrence of extended spectrum beta-lactamases among Enterobacteriaceae spp. isolated at a tertiary care institute. Kumar M S; Lakshmi V; Rajagopalan R Discovery Research, Dr. Reddy's Laboratories Ltd., Hyderabad - 500 049, India. sitaramkumarm@gmail.com Indian journal of medical microbiology (2006), 24(3), 208-11.
  49. Bibliographic Information
    Insulin sensitizing property of Indigofera mysorensis extract. Chakrabarti Ranjan; Damarla Ravi K B; Mullangi Ramesh; Sharma V M; Vikramadithyan Reeba K; Rajagopalan Ramanujam Preclinical Biology, Dr. Reddy's Laboratories - Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 049, India. Journal of ethnopharmacology (2006), 105(1-2), 102-6.
  50. Bibliographic Information
    Dual PPAR-alpha and -gamma activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential. Madhavan Gurram R; Chakrabarti Ranjan; Reddy K Anantha; Rajesh B M; Balraju V; Rao P Bheema; Rajagopalan R; Iqbal Javed Discovery Chemistry, Dr. Reddy's Laboratories Ltd., Bollarum Road, Miyapur, Hyderabad 500049, India. madhavangr@rediffmail.com Bioorganic & medicinal chemistry (2006), 14(2), 584-91.
  51. Bibliographic Information
    DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells. Satyanarayana Chitkala; Deevi Dhanavanthri S; Rajagopalan R; Srinivas Nanduri; Rajagopal Sriram Discovery Research, Dr, Reddy's Laboratories, Bollaram Road, Miyapur, Hyderabad-500049, India. BMC cancer (2004), 4 26.
  52. Bibliographic Information
    Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma. Chakrabarti Ranjan; Misra Parimal; Vikramadithyan Reeba K; Premkumar Mamnoor; Hiriyan Jagadheshan; Datla Srinivas R; Damarla Ravi K B; Suresh Juluri; Rajagopalan Ramanujam Discovery Biology, Dr. Reddy's Laboratory-Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 049, India. European journal of pharmacology (2004), 491(2-3), 195-206.
  53. Bibliographic Information
    Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. Rajagopal Sriram; Kumar R Ajaya; Deevi Dhanvanthri S; Satyanarayana Chitkala; Rajagopalan R Discovery Research, Dr. Reddy's Laboratories, Miyapur, Hyderabad, India-500050. Journal of experimental therapeutics & oncology (2003), 3(3), 147-58.
  54. Bibliographic Information
    Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models. Chakrabarti Ranjan; Vikramadithyan Reeba K; Misra Parimal; Hiriyan Jagadheshan; Raichur Suryaprakash; Damarla Ravi K; Gershome Cynthia; Suresh Juluri; Rajagopalan Ramanujam Discovery Biology, Dr Reddy's Laboratories-Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 050, India British journal of pharmacology (2003), 140(3), 527-37.
  55. Bibliographic Information
    Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats. Mamidi Rao N V S; Mullangi Ramesh; Kota Jagannath; Bhamidipati Ravikanth; Khan Ansar A; Katneni Kasiram; Datla Srinivasaraju; Singh Sunil K; Rao Koteswar Y; Rao C Seshagiri; Srinivas Nuggehally R; Rajagopalan Ramanujam Laboratories of Bioanalysis, Drug Metabolism and Pharmacokinetics, Dr Reddy's Research Foundation, Miyapur, Hyderabad 500 050, India Biopharmaceutics & drug disposition (2002), 23(7), 273-82.
  56. Bibliographic Information
    Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic
    oxazolidinones. Selvakumar Natesan; Srinivas Deekonda; Khera Manoj Kumar; Kumar Magadi Sitaram; Mamidi Rao N V S; Sarnaik Hemanth; Charavaryamath Chandrashekar; Rao Bonthu Srinivasa; Raheem Mohammed A; Das Jagattaran; Iqbal Javed; Rajagopalan Ramanujam Anti-Infectives Discovery Group, Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India Journal of medicinal chemistry (2002), 45(18), 3953-62.
  57. Bibliographic Information
    PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes. Chakrabarti R; Vikramadithyan R K; Kumar M Prem; Kumar S K B; Mamidi N V S; Misra P; Suresh J; Hiriyan J; Rao C S; Rajagopalan R Discovery Biology, Dr Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad, India. Diabetes, obesity & metabolism (2002), 4(5), 319-28.
  58. Bibliographic Information
    Antidiabetic and hypolipidemic activity of Helicteres isora in animal models. Chakrabarti Ranjan; Vikramadithyan Reeba K; Mullangi Ramesh; Sharma V M; Jagadheshan H; Rao Y N; Sairam P; Rajagopalan R Discovery Biology, Dr Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India. Journal of ethnopharmacology (2002), 81(3), 343-9.
  59. Bibliographic Information
    In search of novel water soluble forskolin analogues for positive inotropic activity. Lal B; Gangopadhyay A K; Gidwani R M; Fernandes M; Rajagopalan R; Ghate A V Department of Chemistry, Hoechst Marion Roussel Limited, Mumbai, India. Bioorganic & medicinal chemistry (1998), 6(11), 2075-83.
  60. Bibliographic Information
    Hydroxyacyl derivatives of forskolin--their positive inotropic activity. Lal B; Gangopadhyay A K; Rajagopalan R; Ghate A V Department of Chemistry, Hoechst Marion Roussel Limited, Mumbai, India. Bioorganic & medicinal chemistry (1998), 6(11), 2061-73.  
  61. Bibliographic Information
    Novel euglycemic and hypolipidemic agents: Part-2. Antioxidant moiety as structural motif. :  Reddy K A; Lohray B B; Bhushan V; Reddy A S; Kishore P H; Rao V V; Saibaba V; Bajji A C; Rajesh B M; Reddy K V; Chakrabarti R; Rajagopalan R Dr. Reddy's Research Foundation, Hyderabad, India Bioorganic & medicinal chemistry letters (1998), 8(9), 999-1002.
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