:: Affiliated to the Tamilnadu Dr. M.G.R. Medical University, University of Madras
  :: ‘ICMR Advanced Centre for Genomics of Type 2 Diabetes’ :: IDF Centre for Education
Home
Locate us
 
 
About us
Research Departments
Research Publications
Advisory Committee
Collaboration
Central Lab Facilities
Doctoral Programs
Training Programs
Careers
Guest Book
Contact us


Research Biochemistry
Current activities Past activities  

The Department of Biochemistry focuses on the study of the chemistry behind biological processes and the synthesis of biologically active molecules. Our team of researchers study the chemical properties [role, function, and structure] of biological molecules, like; proteins, lipids and carbohydrates and the changes in their role, function, and structure caused by Diabetes mellitus.

 
  Vision
 
 

To study the chemical properties of biological molecules, like; proteins, lipids and carbohydrates and the changes in their role, function, and structure caused by Diabetes mellitus.

 
  Mission  
 

To focus on and study biomolecules related to energy storage, genetic abnormalities that manifest as the various sub-types of Diabetes [MODY, LADA, IDDM], cell to cell interactions and communications

 
 

The present agenda of the department is to identify new biomarkers associated with diabetes and its complications. In this connection the department liaises with the department of epidemiology and genetics for the following state and national level projects

  • PACE
  • CURES
 
  #  
 

Portfolio of Current Activities of the Department

 
 

Determining if Low levels of HDL in Asian Indians is an indicator of increased risk for coronary artery disease

The higher prevalence of low HDL cholesterol and the young age at which individuals exhibit this phenotype along with the greater propensity for Asian Indians to develop insulin resistance and IGT Low levels of HDL cholesterol are associated with increased risk of coronary artery disease (CAD), and this relationship remains after correction for obesity, age, blood pressure (BP), total cholesterol, or LDL cholesterol levels. There are several genetic diseases associated with low HDL cholesterol .These genetic diseases, however, are very rare, and the presence of isolated low HDL cholesterol in a large proportion of the population remains largely unexplained. The knowledge that both isolated low HDL cholesterol and low HDL/high TG occur more commonly in Asian Indians suggests the possibility that the genetic predisposition to insulin resistance manifest as low HDL cholesterol may be permissive, requires weight gain to cause the expression of the full syndrome comprising dyslipidemia, hypertension, glucose intolerance, and hyperinsulinemia. The question that needs answering is the reason behind low levels of HDL cholesterol being linked to a higher risk for CVD in Asian Indians and high HDL cholesterol levels being associated with a lower risk for CVD in Asian Indians. 

Quantification of Serum 1, 5-Anhydroglucitol in Diabetic Patients

There is a constant need for newer and better markers that respond rapidly and significantly to changes in glycemia, are metabolically stable, demonstrate low biological variability, and can be easily measured to be useful in management of diabetes. 1,5-Anhydroglucitol (1,5AG) has been recently proposed as a marker conforming to these criteria. Our aim is to evaluate the use of serum 1,5-anhydro-d-glucitol (1,5-AG) level as a possible marker for glucose in  Maturity Onset Diabetes of the young (MODY).

 
  #  
  Portfolio of Past Activities of the Department  
 

Areas previously worked on by the department include
a) Diabetes,
b) Insulin Resistance (IR) and
c) Predictor/ markers for diabetes, CAD

  1. Inflammatory markers TNFα’s role and hsCRP in pathogenesis of diabetes
  2. Lipid subfractions, small dense LDL, oxidized LDL,
  3. Platelet activation factor, CD 40l, P-selectin and adiponectin.

In this connection the department collaborated with the departments of epidemiology and genetics for the following state and national level projects:

  1. CUPS
  2. CURES
  3. IDSP
 
  Facilities  
  Equipment to carry out basic biochemical assay, the auto bio analyzer ROCHE Cobas Integra 400 plus and the ELISA.  
  Research Team  
 

Ms. Vijaya Chandrika

Research Fellow

 
     
 
 
  #  
 
Designed & Maintained by Dept of Information Technology, Dr. Mohan's DSC & MDRF