Chennai Urban Population Study [CUPS]:
This was the first epidemiological study carried out by MDRF between 1996 and 1998 to look at the intra urban differences in the prevalence of metabolic syndrome. This study reported on the prevalence of diabetes, impaired glucose tolerance (IGT) and other features of the metabolic syndrome like insulin resistance, hyperlipidemia, hypertension and obesity in two socio economically different sections of society within an urban environment and also reported on the differences in risk factor profiles within these two strata of society.
Two residential colonies were selected in urban Chennai, representing middle income and low income group. This cross-secional field survey was conducted in these two colonies and all individuals aged ≥20 years residing there were invited to participate in the study. Of the total 1,399 eligible subjects, 1,262 individuals participated in the study. Several publications have come out from this study.
Chennai Urban Rural Epidemiology Study (CURES):
Chennai Urban Rural Epidemiology Study (CURES), started in 2001, is a large epidemiologic study involving a representative population of Chennai with the main objective to estimate the prevalence of diabetes and its complications in urban Indians and to identify the risk factors for non-communicable diseases (NCDs). CURES studied 26,001 individuals aged 20 years and above in Chennai. To date, more than 70 publications have resulted from CURES.
Prospective Urban and Rural Epidemiology (PURE) Study:
The Prospective Urban and Rural Epidemiological (PURE) study, is a prospective cohort study that will track changing lifestyles, risk factors and chronic disease using periodic standardized data collection in urban and rural areas of 14 countries: Argentina, Brazil, Canada, Chile, China, Colombia, India, Iran, Kenya, Russia, South Africa, Thailand, United Arab Emirates and Zimbabwe. The main objective of this study is to determine whether variations in the structure of urban and rural societies lead to differences in lifestyle, including nutrition, physical activity patterns and psychosocial stress and whether these in turn lead to the development of risk factors for coronary heart disease. MDRF is one of the five centres in India where the study is being carried out.
WHO Stepwise approach for non-communicable diseases:
The WHO stepwise approach for non-communicable diseases is a large multi centric cross–sectional survey conducted in five centres in India using standardized protocol. The main objective of the study is to develop modules for surveillance of major NCD risk factors within the region, and secondly to formulate and implement the methodology for NCD risk factor surveillance which can be later translated to the national / existing health information systems.
MDRF – WDF Rural Diabetes project :
The MDRF-WDF rural diabetes telemedicine project is a three year project, which is being conducted in a cluster of villages at Chunampet in Kancheepuram District, Tamilnadu about 100 Km from Chennai with the following objectives:
- To implement prevention of diabetes at three levels i.e. Primary prevention (prevention of diabetes itself), Secondary prevention (prevention of diabetes related complications by good diabetes control) and Tertiary prevention (prevention of end stage complications and providing rehabilitation measures) in a rural area in Tamil Nadu in southern India as a model for prevention of diabetes in rural India and other developing countries.
- To encourage community participation and empowering the local people especially women and youth to become educators and spokespersons to adopt a healthy lifestyle and thereby play a significant role in preventing diabetes in the family and in the community at large.
- To screen for diabetes (self reported plus newly detected) and ‘pre-diabetes’ i.e. impaired glucose tolerance.
- To screen for diabetic complications in diabetic subjects in rural areas with particular respect to eye, foot, kidney and heart complications using telemedicine as a novel tool.
Integrated Disease Surveillance Project (IDSP):
The objectives of this project are
This is the surveillance project of non-communicable diseases proposed to be carried out in all states in India by Indian Council of Medical Research (ICMR) and the Ministry of Health and Family Welfare, Government of India. For the state of Tamilnadu, MDRF has been designated as the surveillance centre to conduct this project.
- To estimate the prevalence and distribution of risk factors of NCD’s in different strata in various States/ Regions of India.
- To establish a data base of NCD risk factors and monitor trends of important risk factors over a period of time.
- To support evolving strategies and interventions of identified risk factors to reduce the burden of diseases due to non-communicable diseases.
Indian Diabetes Risk Score (IDRS) Validation Study:
This study was conducted to externally validate the diabetes risk score developed by MDRF. Indian Diabetes Risk Score [IDRS] was developed based on the phase 3 data from CURES.
This simplified Indian Diabetes Risk Score is useful for identifying undiagnosed diabetic subjects in India and could make screening programmes more cost effective as it can reduce the cost by 50% if replaced for screening programmes with blood sugar estimations. IDRS Validation study was conducted to externally validate the risk score.
Sentinel Surveillance System for Cardiovascular Disease in Indian Industrial Population:
Sentinel surveillance system is a study for monitoring cardiovascular disease risk factors and mortality in India. The study population is drawn from 10 major cities in India covering the 6 major regions. A large industry of at least 5000 workers was recruited from each of these regions and all the industry workers and members of their households contribute to the study population. The objectives of this study are as follows:
- To establish sentinel surveillance of cardiovascular risk factors, cardiovascular mortality in industrial population.
- To impart health education to the industrial populations in prevention of cardiovascular diseases.
- To determine the nutritional component in sub samples of the industrial population.
Indian Council of Medical Research – India Diabetes study (ICMR- INDIAB):
The ICMR-INDIAB study is to date the largest epidemiological survey undertaken by MDRF. This study, conducted in collaboration with the Indian Council of Medical Research, aims at determining the nationwide prevalence of diabetes mellitus, by estimating the statewise prevalence of the same.
The study will involve individuals aged 20 years and above, from all the 28 states and two of the Union Territories of India. In addition to finding out the prevalence of diabetes, ICMR-INDIAB is also expected to provide valuable data on pre-diabetes in India, as well as parameters such as hyperlipidemia, and hypertension. The study will also enable us to compare the prevalence of diabetes between states and regions of India.
Influence of Heritability on Glucose Intolerance and Metabolic Syndrome in Adolescents (HEGLINA):
The objective was to study the influence of parental history of type 2 diabetes mellitus on prevalence of the metabolic syndrome (MS) and other Cardiometabolic risk factors in Asian Indian adolescents. This is a cross sectional, case control study. This study showed that parental history of type 2 diabetes mellitus increases risk of not only glucose intolerance but also other cardiometabolic risk factors like overweight, low high-density lipoprotein cholesterol, and high blood pressure in Asian Indian adolescents.
Family Genetic Study:
The main objective of this study is to determine the genetic basis of diabetes and its complications. Large families with several diabetic subjects were selected from the pedigrees collected from the CURES study and all the adult family members (aged ≥20 years) were invited to participate in this study to determine the genetic basis of diabetes and its complications.
Schizophrenia and diabetes:
The aim of this study was to determine the prevalence of diabetes, metabolic syndrome and obesity among subjects with schizophrenia.
International Student’ projects:
Fullbright scholar project:
Population Experiences, Awareness and Conceptions of Health (PEACH): This study was conducted by a student from Michigan University, Ms. Heather E. Lanthorn, with the main objective to look at the perceptions about risk factors for non communicable diseases in urban south India.
Project done by student’s from Emory University, USA.
- Caregiver child feeding practices in Asiad Colony, Chennai.
- Diabetes related knowledge and behaviour among adolescents(12-16years) in Chennai, India.
- Assessing Health Related Quality of life in Patients with Diabetic Retinopathy and Diabetic Macular Edema.